An atlas for Schistosoma mansoni organs and life-cycle stages using cell type-specific markers and confocal microscopy.

ABSTRACT: Schistosomiasis (bilharzia) is a tropical disease caused by trematode parasites (Schistosoma) that affects hundreds of millions of people in the developing world. Currently only a single drug (praziquantel) is available to treat this disease, highlighting the importance of developing new techniques to study Schistosoma. While molecular advances, including RNA interference and the availability of complete genome sequences for two Schistosoma species, will help to revolutionize studies of these animals, an array of tools for visualizing the consequences of experimental perturbations on tissue integrity and development needs to be made widely available. To this end, we screened a battery of commercially available stains, antibodies and fluorescently labeled lectins, many of which have not bee

SUBMITTER: Collins JJ 

PROVIDER: S-EPMC3050934 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature