Ontology highlight
ABSTRACT:
SUBMITTER: Peng H
PROVIDER: S-EPMC3051063 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Peng Huiming H Wen Jianguo J Li Hongwei H Chang Jeff J Zhou Xiaobo X
PloS one 20110307 3
Nuclear factor κB (NFκB) activation plays a crucial role in anti-apoptotic responses in response to the apoptotic signaling during tumor necrosis factor (TNFα) stimulation in Multiple Myeloma (MM). Although several drugs have been found effective for the treatment of MM by mainly inhibiting NFκB pathway, there are not any quantitative or qualitative results of comparison assessment on inhibition effect between different drugs either used alone or in combinations. Computational modeling is becomi ...[more]