Ontology highlight
ABSTRACT:
SUBMITTER: Weinreich MA
PROVIDER: S-EPMC3051359 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Weinreich Michael A MA Odumade Oludare A OA Jameson Stephen C SC Hogquist Kristin A KA
Nature immunology 20100704 8
Several gene-deficiency models promote the development of innate CD8(+) T cells that have diverse T cell antigen receptors (TCRs) but have a memory phenotype and rapidly produce cytokines. We demonstrate here that similar cells developed in mice deficient in the transcription factor KLF2. However, this was not due to intrinsic deficiency in KLF2 but instead was due to interleukin 4 (IL-4) produced by an expanded population of T cells expressing the transcription factor PLZF. The development of i ...[more]