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(3R*,4R*)-1-(4-Chloro-phen-yl)-4-[2-hy-droxy-3-(morpholinomethyl)-phen-yl]-3-phen-oxy-azetidin-2-one.

ABSTRACT: The ?-lactam ring of the title compound, C(26)H(25)ClN(2)O(4), is nearly planar (r.m.s. deviation = 0.025?Å) and the morpholine ring adopts a chair conformation. The mean plane of the ?-lactam ring makes dihedral angles of 21.6?(4), 84.4?(4) and 33.7?(4)° with the two benzene rings and the phenyl ring, respectively. The conformation of the title compound is stabilized by intra-molecular C-H?O and O-H?N inter-actions. The crystal structure features C-H?? and aromatic ?-? stacking inter-actions [centroid-centroid distances = 3.684?(4) and 3.883?(4)?Å].

SUBMITTER: Akkurt M 

PROVIDER: S-EPMC3051698 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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(3R*,4R*)-1-(4-Chloro-phen-yl)-4-[2-hy-droxy-3-(morpholinomethyl)-phen-yl]-3-phen-oxy-azetidin-2-one.

Akkurt Mehmet M   Jarrahpour Aliasghar A   Sharghi Hashem H   Badrabady Seid Ali Torabi SA   Büyükgüngör Orhan O  

Acta crystallographica. Section E, Structure reports online 20110112 Pt 2

The β-lactam ring of the title compound, C(26)H(25)ClN(2)O(4), is nearly planar (r.m.s. deviation = 0.025 Å) and the morpholine ring adopts a chair conformation. The mean plane of the β-lactam ring makes dihedral angles of 21.6 (4), 84.4 (4) and 33.7 (4)° with the two benzene rings and the phenyl ring, respectively. The conformation of the title compound is stabilized by intra-molecular C-H⋯O and O-H⋯N inter-actions. The crystal structure features C-H⋯π and aromatic π-π stacking inter-actions [c  ...[more]

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