Ontology highlight
ABSTRACT:
SUBMITTER: Yu YV
PROVIDER: S-EPMC3051913 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Yu Yanxun V YV Li Zhihuan Z Rizzo Nicholas P NP Einstein Jenifer J Welte Michael A MA
BMC cell biology 20110224
<h4>Background</h4>In Drosophila, the transport regulator Klar displays tissue-specific localization: In photoreceptors, it is abundant on the nuclear envelope; in early embryos, it is absent from nuclei, but instead present on lipid droplets. Differential targeting of Klar appears to be due to isoform variation. Droplet targeting, in particular, has been suggested to occur via a variant C-terminal region, the LD domain. Although the LD domain is necessary and sufficient for droplet targeting in ...[more]