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2-{2-[4-(4-Fluoro-phen-yl)piperazin-1-yl]-2-oxoeth-yl}-6-(morpholin-4-yl)-4-phenyl-pyridazin-3(2H)-one.

ABSTRACT: In the title compound, C(26)H(28)FN(5)O(3), the morpholine ring adopts a chair conformation. The piperazine ring is puckered [Q(T) = 0.5437?(15)?Å, ? = 8.89?(15) and ? = 357.2?(11)°]. The 1,6-dihydro-pyridazine ring makes dihedral angles of 28.03?(7) and 77.46?(7)° with the phenyl and benzene rings, respectively. In the crystal, mol-ecules are linked along the c axis by C-H?O inter-actions and are flattened parallel to the ac plane. C-H?? inter-actions also contribute to the stability of the structure.

SUBMITTER: Ayd?n A

PROVIDER: S-EPMC3052151 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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2-{2-[4-(4-Fluoro-phen-yl)piperazin-1-yl]-2-oxoeth-yl}-6-(morpholin-4-yl)-4-phenyl-pyridazin-3(2H)-one.

Aydın Abdullah A Süküroğlu Murat M Akkurt Mehmet M Büyükgüngör Orhan O

Acta crystallographica. Section E, Structure reports online 20110219 Pt 3

In the title compound, C(26)H(28)FN(5)O(3), the morpholine ring adopts a chair conformation. The piperazine ring is puckered [Q(T) = 0.5437 (15) Å, θ = 8.89 (15) and ϕ = 357.2 (11)°]. The 1,6-dihydro-pyridazine ring makes dihedral angles of 28.03 (7) and 77.46 (7)° with the phenyl and benzene rings, respectively. In the crystal, mol-ecules are linked along the c axis by C-H⋯O inter-actions and are flattened parallel to the ac plane. C-H⋯π inter-actions also contribute to the stability of the str ...[more]

PMID: 21522416

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Crystal structure of 4-(4-chloro-phen-yl)-6-(morpholin-4-yl)pyridazin-3(2H)-one.

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