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Endocrine regulation of male fertility by the skeleton.

ABSTRACT: Interactions between bone and the reproductive system have until now been thought to be limited to the regulation of bone remodeling by the gonads. We now show that, in males, bone acts as a regulator of fertility. Using coculture assays, we demonstrate that osteoblasts are able to induce testosterone production by the testes, though they fail to influence estrogen production by the ovaries. Analyses of cell-specific loss- and gain-of-function models reveal that the osteoblast-derived hormone osteocalcin performs this endocrine function. By binding to a G protein-coupled receptor expressed in the Leydig cells of the testes, osteocalcin regulates in a CREB-dependent manner the expression of enzymes that is required for testosterone synthesis, promoting germ cell survival. This study expands the physiological repertoire of osteocalcin and provides the first evidence that the skeleton is an endocrine regulator of reproduction.

SUBMITTER: Oury F

PROVIDER: S-EPMC3052787 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Endocrine regulation of male fertility by the skeleton.

Oury Franck F Sumara Grzegorz G Sumara Olga O Ferron Mathieu M Chang Haixin H Smith Charles E CE Hermo Louis L Suarez Susan S Roth Bryan L BL Ducy Patricia P Karsenty Gerard G

Cell 20110217 5

Interactions between bone and the reproductive system have until now been thought to be limited to the regulation of bone remodeling by the gonads. We now show that, in males, bone acts as a regulator of fertility. Using coculture assays, we demonstrate that osteoblasts are able to induce testosterone production by the testes, though they fail to influence estrogen production by the ovaries. Analyses of cell-specific loss- and gain-of-function models reveal that the osteoblast-derived hormone os ...[more]

PMID: 21333348

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2022-10-13 | PXD033872 | Pride

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