Ontology highlight
ABSTRACT:
SUBMITTER: Martins-Silva C
PROVIDER: S-EPMC3053374 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Martins-Silva Cristina C De Jaeger Xavier X Guzman Monica S MS Lima Ricardo D F RD Santos Magda S MS Kushmerick Christopher C Gomez Marcus V MV Caron Marc G MG Prado Marco A M MA Prado Vania F VF
PloS one 20110310 3
Defining the contribution of acetylcholine to specific behaviors has been challenging, mainly because of the difficulty in generating suitable animal models of cholinergic dysfunction. We have recently shown that, by targeting the vesicular acetylcholine transporter (VAChT) gene, it is possible to generate genetically modified mice with cholinergic deficiency. Here we describe novel VAChT mutant lines. VAChT gene is embedded within the first intron of the choline acetyltransferase (ChAT) gene, w ...[more]