Ontology highlight
ABSTRACT:
SUBMITTER: Yassin AS
PROVIDER: S-EPMC3053986 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Yassin Aymen S AS Haque Md Emdadul ME Datta Partha P PP Elmore Kevin K Banavali Nilesh K NK Spremulli Linda L LL Agrawal Rajendra K RK
Proceedings of the National Academy of Sciences of the United States of America 20110222 10
Mitochondria have their own translational machineries for the synthesis of thirteen polypeptide chains that are components of the complexes that participate in the process of oxidative phosphorylation (or ATP generation). Translation initiation in mammalian mitochondria requires two initiation factors, IF2(mt) and IF3(mt), instead of the three that are present in eubacteria. The mammalian IF2(mt) possesses a unique 37 amino acid insertion domain, which is known to be important for the formation ...[more]