Ontology highlight
ABSTRACT:
SUBMITTER: Guo Z
PROVIDER: S-EPMC3054037 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Guo Zuojun Z Gibson Meghan M Sitha Sanyasi S Chu Steven S Mohanty Udayan U
Proceedings of the National Academy of Sciences of the United States of America 20110222 10
The fidelity of translation selection begins with the base pairing of codon-anticodon complex between the m-RNA and tRNAs. Binding of cognate and near-cognate tRNAs induces 30S subunit of the ribosome to wrap around the ternary complex, EF-Tu(GTP)aa-tRNA. We have proposed that large thermal fluctuations play a crucial role in the selection process. To test this conjecture, we have developed a theoretical technique to determine the probability that the ternary complex, as a result of large therma ...[more]