Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts novelty seeking and harm avoidance.
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ABSTRACT:
SUBMITTER: Montag C
PROVIDER: S-EPMC3055626 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
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Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts novelty seeking and harm avoidance.
Montag Christian C Markett Sebastian S Basten Ulrike U Stelzel Christine C Fiebach Christian C Canli Turhan T Reuter Martin M
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100421 9
Mounting evidence from animal studies show that the mesolimbic dopaminergic pathways are modulated by the brain-derived neurotrophic factor (BDNF). This study investigates in N=768 healthy Caucasian participants the influence of two prominent functional single-nucleotide polymorphisms (SNPs) on the BDNF gene (BDNF Val66Met SNP) and the ankyrin repeat and kinase domain containing 1 (ANKK1) gene (DRD2 Taq Ia/ANKK1 SNP) on the personality traits of Novelty Seeking and Harm Avoidance, which are medi ...[more]
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