Ontology highlight
ABSTRACT:
SUBMITTER: Vallee F
PROVIDER: S-EPMC305596 | biostudies-literature | 2000 Feb
REPOSITORIES: biostudies-literature
Vallée F F Lipari F F Yip P P Sleno B B Herscovics A A Howell P L PL
The EMBO journal 20000201 4
Mannose trimming is not only essential for N-glycan maturation in mammalian cells but also triggers degradation of misfolded glycoproteins. The crystal structure of the class I alpha1, 2-mannosidase that trims Man(9)GlcNAc(2) to Man(8)GlcNAc(2 )isomer B in the endoplasmic reticulum of Saccharomyces cerevisiae reveals a novel (alphaalpha)(7)-barrel in which an N-glycan from one molecule extends into the barrel of an adjacent molecule, interacting with the essential acidic residues and calcium ion ...[more]