Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation.
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ABSTRACT:
SUBMITTER: Jin DY
PROVIDER: S-EPMC305611 | biostudies-literature | 2000 Feb
REPOSITORIES: biostudies-literature
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Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation.
Jin D Y DY Wang H L HL Zhou Y Y Chun A C AC Kibler K V KV Hou Y D YD Kung H H Jeang K T KT
The EMBO journal 20000201 4
Hepatitis C virus (HCV) is the major etiological agent of blood-borne non-A non-B hepatitis and a leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. HCV core protein is a multifunctional protein with regulatory functions in cellular transcription and virus-induced transformation and pathogenesis. Here we report on the identification of a bZIP nuclear transcription protein as an HCV core cofactor for transformation. This bZIP factor, designated LZIP, activates CRE-dependent ...[more]
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