Ontology highlight
ABSTRACT:
SUBMITTER: Zou J
PROVIDER: S-EPMC3056331 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Developmental cell 20110101 1
mTor kinase is involved in cell growth, proliferation, and differentiation. The roles of mTor activators, Rheb1 and Rheb2, have not been established in vivo. Here, we report that Rheb1, but not Rheb2, is critical for embryonic survival and mTORC1 signaling. Embryonic deletion of Rheb1 in neural progenitor cells abolishes mTORC1 signaling in developing brain and increases mTORC2 signaling. Remarkably, embryonic and early postnatal brain development appears grossly normal in these Rheb1f/f,Nes-cre ...[more]