Ontology highlight
ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC3056605 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Journal of cell science 20110401 Pt 7
Notch receptors and their ligands have crucial roles in development and tumorigenesis. We present evidence demonstrating the existence of an antagonistic relationship between Notch 4 and Trp53, which is controlled by the Mdm2-dependent ubiquitylation and degradation of the Notch receptor. We show that this signal-controlling mechanism is mediated by physical interactions between Mdm2 and Notch 4 and suggest the existence of a trimeric complex between Trp53, Notch 4 and Mdm2, which ultimately reg ...[more]