Ontology highlight
ABSTRACT:
SUBMITTER: Slager SL
PROVIDER: S-EPMC3056639 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Slager Susan L SL Rabe Kari G KG Achenbach Sara J SJ Vachon Celine M CM Goldin Lynn R LR Strom Sara S SS Lanasa Mark C MC Spector Logan G LG Rassenti Laura Z LZ Leis Jose F JF Camp Nicola J NJ Glenn Martha M Kay Neil E NE Cunningham Julie M JM Hanson Curtis A CA Marti Gerald E GE Weinberg J Brice JB Morrison Vicki A VA Link Brian K BK Call Timothy G TG Caporaso Neil E NE Cerhan James R JR
Blood 20101203 6
Prior genome-wide association (GWA) studies have identified 10 susceptibility loci for risk of chronic lymphocytic leukemia (CLL). To identify additional loci, we performed a GWA study in 407 CLL cases (of which 102 had a family history of CLL) and 296 controls. Moreover, given the strong familial risk of CLL, we further subset our GWA analysis to the CLL cases with a family history of CLL to identify loci specific to these familial CLL cases. Our top hits from these analyses were evaluated in a ...[more]