Ontology highlight
ABSTRACT:
SUBMITTER: Balda MS
PROVIDER: S-EPMC305688 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
The EMBO journal 20000501 9
Epithelial tight junctions regulate paracellular diffusion and restrict the intermixing of apical and basolateral plasma membrane components. We now identify a Y-box transcription factor, ZONAB (ZO-1-associated nucleic acid-binding protein), that binds to the SH3 domain of ZO-1, a submembrane protein of tight junctions. ZONAB localizes to the nucleus and at tight junctions, and binds to sequences of specific promoters containing an inverted CCAAT box. In reporter assays, ZONAB and ZO-1 functiona ...[more]