NSAID-induced deleterious effects on the proximal and mid small bowel in seronegative spondyloarthropathy patients.

ABSTRACT:

Aim

To investigate the small bowel of seronegative spondyloarthropathy (SpA) patients in order to ascertain the presence of mucosal lesions.

Methods

Between January 2008 and June 2010, 54 consecutive patients were enrolled and submitted to a video capsule endoscopy (VCE) examination. History and demographic data were taken, as well as the history of non-steroidal anti-inflammatory drug (NSAID) consumption. After reading each VCE recording, a capsule endoscopy scoring index for small bowel mucosal inflammatory change (Lewis score) was calculated. Statistical analysis of the data was performed.

Results

The Lewis score for the whole cohort was 397.73. It was higher in the NSAID consumption subgroup (P = 0.036). The difference in Lewis score between NSAID users and non-us

SUBMITTER: Rimbas M 

PROVIDER: S-EPMC3057146 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature