Ontology highlight
ABSTRACT:
SUBMITTER: Shaw PJ
PROVIDER: S-EPMC3057380 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Shaw Patrick J PJ Barr Maggie J MJ Lukens John R JR McGargill Maureen A MA Chi Hongbo H Mak Tak W TW Kanneganti Thirumala-Devi TD
Immunity 20110113 1
Peripheral peptidolgycan (PGN) is present within antigen-presenting cells in the central nervous system (CNS) of multiple sclerosis (MS) patients, possibly playing a role in neuroinflammation. Accordingly, PGN is linked with disease progression in the animal model of MS, experimental autoimmune encephalomyelitis (EAE), but the role of specific PGN-sensing proteins is unknown. Here we report that the progression of EAE was dependent on the intracellular PGN sensors NOD1 and NOD2 and their common ...[more]