The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1?/ATF6? complex.
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ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC3057411 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
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The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex.
Wu Jun J Ruas Jorge L JL Estall Jennifer L JL Rasbach Kyle A KA Choi Jang Hyun JH Ye Li L Boström Pontus P Tyra Heather M HM Crawford Robert W RW Campbell Kevin P KP Rutkowski D Thomas DT Kaufman Randal J RJ Spiegelman Bruce M BM
Cell metabolism 20110201 2
Exercise has been shown to be effective for treating obesity and type 2 diabetes. However, the molecular mechanisms for adaptation to exercise training are not fully understood. Endoplasmic reticulum (ER) stress has been linked to metabolic dysfunction. Here we show that the unfolded protein response (UPR), an adaptive response pathway that maintains ER homeostasis upon luminal stress, is activated in skeletal muscle during exercise and adapts skeletal muscle to exercise training. The transcript ...[more]
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