Hereditary and familial colon cancer.
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ABSTRACT:
SUBMITTER: Jasperson KW
PROVIDER: S-EPMC3057468 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Hereditary and familial colon cancer.
Jasperson Kory W KW Tuohy Thérèse M TM Neklason Deborah W DW Burt Randall W RW
Gastroenterology 20100601 6
Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and certain hamartomatous polyposis conditions. Each is associated with a high risk of colon cancer. In addition to the syndromes, up to one-third of colon cancers exhibit increased familial risk, likely related to inheritance. A number of less penetrant, but possibly more frequent susceptibility genes have been iden ...[more]
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