Ontology highlight
ABSTRACT:
SUBMITTER: Matsushita E
PROVIDER: S-EPMC3057699 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Matsushita Etsushi E Asai Naoya N Enomoto Atsushi A Kawamoto Yoshiyuki Y Kato Takuya T Mii Shinji S Maeda Kengo K Shibata Rei R Hattori Shun S Hagikura Minako M Takahashi Ken K Sokabe Masahiro M Murakumo Yoshiki Y Murohara Toyoaki T Takahashi Masahide M
Molecular biology of the cell 20110202 6
Continued exposure of endothelial cells to mechanical/shear stress elicits the unfolded protein response (UPR), which enhances intracellular homeostasis and protect cells against the accumulation of improperly folded proteins. Cells commit to apoptosis when subjected to continuous and high endoplasmic reticulum (ER) stress unless homeostasis is maintained. It is unknown how endothelial cells differentially regulate the UPR. Here we show that a novel Girdin family protein, Gipie (78 kDa glucose-r ...[more]