Ontology highlight
ABSTRACT:
SUBMITTER: Hennecke J
PROVIDER: S-EPMC305780 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
Hennecke J J Carfi A A Wiley D C DC
The EMBO journal 20001101 21
An alphabeta T-cell receptor (alphabetaTCR)/hemagglutinin (HA) peptide/human leukocyte antigen (HLA)-DR1 complex was stabilized by flexibly linking the HA peptide with the human HA1.7 alphabetaTCR, to increase the local concentration of the interacting proteins once the peptide has been loaded onto the major histocompatibility complex (MHC) molecule. The structure of the complex, determined by X-ray crystallography, has a binding mode similar to that of the human B7 alphabetaTCR on a pMHCI molec ...[more]