Ontology highlight
ABSTRACT:
SUBMITTER: Mas A
PROVIDER: S-EPMC305792 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
Mas A A Parera M M Briones C C Soriano V V Martínez M A MA Domingo E E Menéndez-Arias L L
The EMBO journal 20001101 21
The 3'-azido-3'-deoxythymidine (AZT)-resistant pheno type of a heavily mutated human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) carrying a dipeptide (Ser-Ser) insertion between codons 69 and 70 as well as other mutations related to resistance to RT inhibitors has been studied. Recombinant virus carrying this variant RT (termed SS RT) showed reduced susceptibility to all nucleoside RT inhibitors in clinical use, particularly to AZT. In the presence of ATP, recombinant SS RT ...[more]