Ontology highlight
ABSTRACT:
SUBMITTER: Ossig R
PROVIDER: S-EPMC305815 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
Ossig R R Schmitt H D HD de Groot B B Riedel D D Keränen S S Ronne H H Grubmüller H H Jahn R R
The EMBO journal 20001101 22
Assembly of SNAREs (soluble N:-ethylmaleimide- sensitive factor attachment protein receptors) mediates membrane fusions in all eukaryotic cells. The synaptic SNARE complex is represented by a twisted bundle of four alpha-helices. Leucine zipper-like layers extend through the length of the complex except for an asymmetric and ionic middle layer formed by three glutamines (Q) and one arginine (R). We have examined the functional consequences of Q-R exchanges in the conserved middle layer using the ...[more]