Ontology highlight
ABSTRACT:
SUBMITTER: Ferguson SM
PROVIDER: S-EPMC3058296 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Nature neuroscience 20101205 1
Dorsal striatum is important for the development of drug addiction; however, a precise understanding of the roles of striatopallidal (indirect) and striatonigral (direct) pathway neurons in regulating behaviors remains elusive. Using viral-mediated expression of an engineered G protein-coupled receptor (hM(4)D), we found that activation of hM(4)D receptors with clozapine-N-oxide (CNO) potently reduced striatal neuron excitability. When hM(4)D receptors were selectively expressed in either direct ...[more]