Rapid translocation of nanoparticles from the lung airspaces to the body.
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ABSTRACT:
SUBMITTER: Choi HS
PROVIDER: S-EPMC3058321 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
Rapid translocation of nanoparticles from the lung airspaces to the body.
Choi Hak Soo HS Ashitate Yoshitomo Y Lee Jeong Heon JH Kim Soon Hee SH Matsui Aya A Insin Numpon N Bawendi Moungi G MG Semmler-Behnke Manuela M Frangioni John V JV Tsuda Akira A
Nature biotechnology 20101107 12
Nano-size particles show promise for pulmonary drug delivery, yet their behavior after deposition in the lung remains poorly understood. In this study, a series of near-infrared (NIR) fluorescent nanoparticles were systematically varied in chemical composition, shape, size and surface charge, and their biodistribution and elimination were quantified in rat models after lung instillation. We demonstrate that nanoparticles with hydrodynamic diameter (HD) less than ≈34 nm and a noncationic surface ...[more]
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