Ontology highlight
ABSTRACT:
SUBMITTER: Owen DJ
PROVIDER: S-EPMC305837 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
Owen D J DJ Ornaghi P P Yang J C JC Lowe N N Evans P R PR Ballario P P Neuhaus D D Filetici P P Travers A A AA
The EMBO journal 20001101 22
The bromodomain is an approximately 110 amino acid module found in histone acetyltransferases and the ATPase component of certain nucleosome remodelling complexes. We report the crystal structure at 1.9 A resolution of the Saccharomyces cerevisiae Gcn5p bromodomain complexed with a peptide corresponding to residues 15-29 of histone H4 acetylated at the zeta-N of lysine 16. We show that this bromodomain preferentially binds to peptides containing an N:-acetyl lysine residue. Only residues 16-19 o ...[more]