Ontology highlight
ABSTRACT:
SUBMITTER: Chien EY
PROVIDER: S-EPMC3058422 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Chien Ellen Y T EY Liu Wei W Zhao Qiang Q Katritch Vsevolod V Han Gye Won GW Hanson Michael A MA Shi Lei L Newman Amy Hauck AH Javitch Jonathan A JA Cherezov Vadim V Stevens Raymond C RC
Science (New York, N.Y.) 20101101 6007
Dopamine modulates movement, cognition, and emotion through activation of dopamine G protein-coupled receptors in the brain. The crystal structure of the human dopamine D3 receptor (D3R) in complex with the small molecule D2R/D3R-specific antagonist eticlopride reveals important features of the ligand binding pocket and extracellular loops. On the intracellular side of the receptor, a locked conformation of the ionic lock and two distinctly different conformations of intracellular loop 2 are obs ...[more]