Ontology highlight
ABSTRACT:
SUBMITTER: Pelletier N
PROVIDER: S-EPMC3058870 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Nature immunology 20101031 12
B lymphocytes differentiate into antibody-secreting cells under the antigen-specific control of follicular helper T cells (T(FH) cells). Here we demonstrate that isotype-switched plasma cells expressed major histocompatibility complex (MHC) class II, the costimulatory molecules CD80 and CD86, and the intracellular machinery required for antigen presentation. Antigen-specific plasma cells accessed, processed and presented sufficient antigen in vivo to induce multiple helper T cell functions. Nota ...[more]