Ontology highlight
ABSTRACT:
SUBMITTER: Bugreev DV
PROVIDER: S-EPMC3058924 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20101212 1
The ubiquitously expressed Rad51 recombinase and the meiosis-specific Dmc1 recombinase promote the formation of strand-invasion products (D-loops) between homologous molecules. Strand-invasion products are processed by either the double-strand break repair (DSBR) or synthesis-dependent strand annealing (SDSA) pathway. D-loops destined to be processed by SDSA need to dissociate, producing non-crossovers, and those destined for DSBR should resist dissociation to generate crossovers. The mechanism ...[more]