Ontology highlight
ABSTRACT:
SUBMITTER: Paragas N
PROVIDER: S-EPMC3059503 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Nature medicine 20110116 2
Many proteins have been proposed to act as surrogate markers of organ damage, yet for many candidates the essential biomarker characteristics that link the protein to the injured organ have not yet been described. We generated an Ngal reporter mouse by inserting a double-fusion reporter gene encoding luciferase-2 and mCherry (Luc2-mC) into the Ngal (Lcn2) locus. The Ngal-Luc2-mC reporter accurately recapitulated the endogenous message and illuminated injuries in vivo in real time. In the kidney, ...[more]