Ontology highlight
ABSTRACT:
SUBMITTER: Neilson KM
PROVIDER: S-EPMC3059517 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Neilson Karen M KM Pignoni Francesca F Yan Bo B Moody Sally A SA
Developmental dynamics : an official publication of the American Association of Anatomists 20101201 12
Six family transcription factors play important roles in craniofacial development. Their transcriptional activity can be modified by cofactor proteins. Two Six genes and one cofactor gene (Eya1) are involved in the human Branchio-otic (BO) and Branchio-otic-renal (BOR) syndromes. However, mutations in Six and Eya genes only account for approximately half of these patients. To discover potential new causative genes, we searched the Xenopus genome for orthologues of Drosophila cofactor proteins th ...[more]