The heads of the measles virus attachment protein move to transmit the fusion-triggering signal.
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ABSTRACT:
SUBMITTER: Navaratnarajah CK
PROVIDER: S-EPMC3059746 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
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The heads of the measles virus attachment protein move to transmit the fusion-triggering signal.
Navaratnarajah Chanakha K CK Oezguen Numan N Rupp Levi L Kay Leah L Leonard Vincent H J VH Braun Werner W Cattaneo Roberto R
Nature structural & molecular biology 20110109 2
The measles virus entry system, consisting of attachment (hemagglutinin, H) and fusion proteins, operates by means of a variety of natural and targeted receptors; however, the mechanism that triggers fusion of the viral envelope with the plasma membrane is not understood. Here, we tested a model proposing that the two heads of an H dimer, which are covalently linked at their base, after binding two receptor molecules, move relative to each other to transmit the fusion-triggering signal. Indeed, ...[more]
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