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A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing.

ABSTRACT: We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo-like kinase 1, which is similar to the mitotic prophase pathway.

SUBMITTER: Ishiguro K

PROVIDER: S-EPMC3059921 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing.

Ishiguro Kei-ichiro K Kim Jihye J Fujiyama-Nakamura Sally S Kato Shigeaki S Watanabe Yoshinori Y

EMBO reports 20110128 3

We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements ...[more]

PMID: 21274006

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