Serum uric acid distribution according to SLC22A12 W258X genotype in a cross-sectional study of a general Japanese population.

ABSTRACT:

Background

Although SLC22A12 258X allele was found among those with hypouricemia, it was unknown that serum uric acid distribution among those with SLC22A12 258X allele. This study examined serum uric acid (SUA) distribution according to SLC22A12 W258X genotype in a general Japanese population.

Methods

Subjects were 5,023 health checkup examinees (3,413 males and 1,610 females) aged 35 to 69 years with creatinine <2.0 mg/dL, who were participants of a cohort study belonging to the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). SLC22A12 W258X was genotyped with a polymerase chain reaction with confronting two-pair primers.

Results

The genotype frequency was 4,793 for WW, 225 for WX, and 5 for XX, which was in Hardy-Weinberg equilibrium (p=0.164) w

SUBMITTER: Hamajima N 

PROVIDER: S-EPMC3060108 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature