Ontology highlight
ABSTRACT:
SUBMITTER: Williams CP
PROVIDER: S-EPMC3060121 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Williams Chris P CP Schueller Nicole N Thompson Colin A CA van den Berg Marlene M Van Haren Simon D SD Erdmann Ralf R Bond Charles S CS Distel Ben B Schliebs Wolfgang W Wilmanns Matthias M Stanley Will A WA
BMC biochemistry 20110304
<h4>Background</h4>The majority of peroxisomal matrix proteins destined for translocation into the peroxisomal lumen are recognised via a C-terminal Peroxisomal Target Signal type 1 by the cycling receptor Pex5p. The only structure to date of Pex5p in complex with a cargo protein is that of the C-terminal cargo-binding domain of the receptor with sterol carrier protein 2, a small, model peroxisomal protein. In this study, we have tested the contribution of a second, ancillary receptor-cargo bind ...[more]