Ontology highlight
ABSTRACT:
SUBMITTER: Mercado N
PROVIDER: S-EPMC3061319 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Mercado Nicolas N Thimmulappa Rajesh R Thomas Catherine M R CM Fenwick Peter S PS Chana Kirandeep K KK Donnelly Louise E LE Biswal Shyam S Ito Kazuhiro K Barnes Peter J PJ
Biochemical and biophysical research communications 20110212 2
Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in cellular defence against oxidative stress by inducing the expression of multiple anti-oxidant genes. However, where high levels of oxidative stress are observed, such as chronic obstructive pulmonary disease (COPD), Nrf2 activity is reduced, although the molecular mechanism for this defect is uncertain. Here, we show that down-regulation of histone deacetylase (HDAC) 2 causes Nrf2 instability, resulting in reduced anti-ox ...[more]