Ontology highlight
ABSTRACT:
SUBMITTER: Di Guilmi MN
PROVIDER: S-EPMC3061532 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
The Journal of pharmacology and experimental therapeutics 20101222 3
In this work, we studied the effects of the anticonvulsant and analgesic drug pregabalin (PGB) on excitatory postsynaptic currents (EPSCs) at principal neurons of the mouse medial nucleus of the trapezoid body and on presynaptic calcium currents at the calyx of Held. We found that the acute application of PGB reduced the amplitude of EPSCs in a dose-dependent manner with a maximal blocking effect of approximately 30%. A clinical high-concentration dose of PGB (e.g., 500 μM) blocked Ca(v)2.1 chan ...[more]