Ontology highlight
ABSTRACT:
SUBMITTER: Kashyap MP
PROVIDER: S-EPMC3061860 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Kashyap Mahendra Pratap MP Singh Abhishek Kumar AK Kumar Vivek V Tripathi Vinay Kumar VK Srivastava Ritesh Kumar RK Agrawal Megha M Khanna Vinay Kumar VK Yadav Sanjay S Jain Swatantra Kumar SK Pant Aditya Bhushan AB
PloS one 20110321 3
Monocrotophos (MCP) is a widely used organophosphate (OP) pesticide. We studied apoptotic changes and their correlation with expression of selected cytochrome P450s (CYPs) in PC12 cells exposed to MCP. A significant induction in reactive oxygen species (ROS) and decrease in glutathione (GSH) levels were observed in cells exposed to MCP. Following the exposure of PC12 cells to MCP (10(-5) M), the levels of protein and mRNA expressions of caspase-3/9, Bax, Bcl(2), P(53), P(21), GSTP1-1 were signif ...[more]