Ontology highlight
ABSTRACT:
SUBMITTER: Zhang AH
PROVIDER: S-EPMC3062330 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Zhang Ai-Hong AH Skupsky Jonathan J Scott David W DW
Blood 20101215 7
We herein tested the effect of B-cell depletion on tolerance induction to factor VIII (FVIII) in a mouse model of hemophilia A. Two subclasses of anti-mouse CD20 monoclonal antibodies with differential depletion effects were used. Thus, IgG1 anti-CD20 selectively depleted follicular B cells and spared marginal zone B cells, whereas IgG2a anti-CD20 efficiently depleted both. In FVIII primed mice, a single dose of either IgG1 or IgG2a anti-CD20 pretreatment prevented the increase in inhibitor form ...[more]