Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes.
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ABSTRACT:
SUBMITTER: Refaai MA
PROVIDER: S-EPMC3062691 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
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Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes.
Refaai Majed A MA Phipps Richard P RP Spinelli Sherry L SL Blumberg Neil N
Thrombosis research 20101119 4
Platelet transfusion is one of the most crucial therapeutic approaches in Medicine. However, severe and fatal adverse reactions may develop. In addition to their important function in hemostasis, platelets' role in inflammation has become more evident. Recently, platelets are also recognized as the main source of circulating soluble CD40 ligand (sCD40L, (CD154)), which plays significant roles in hemostasis, platelet activation, clot stability, interactions with other cells, and upregulation of d ...[more]
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