Ontology highlight
ABSTRACT:
SUBMITTER: Chae PS
PROVIDER: S-EPMC3063152 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Chae Pil Seok PS Rasmussen Søren G F SG Rana Rohini R RR Gotfryd Kamil K Chandra Richa R Goren Michael A MA Kruse Andrew C AC Nurva Shailika S Loland Claus J CJ Pierre Yves Y Drew David D Popot Jean-Luc JL Picot Daniel D Fox Brian G BG Guan Lan L Gether Ulrik U Byrne Bernadette B Kobilka Brian B Gellman Samuel H SH
Nature methods 20101031 12
The understanding of integral membrane protein (IMP) structure and function is hampered by the difficulty of handling these proteins. Aqueous solubilization, necessary for many types of biophysical analysis, generally requires a detergent to shield the large lipophilic surfaces of native IMPs. Many proteins remain difficult to study owing to a lack of suitable detergents. We introduce a class of amphiphiles, each built around a central quaternary carbon atom derived from neopentyl glycol, with h ...[more]