Ontology highlight
ABSTRACT:
SUBMITTER: Chae PS
PROVIDER: S-EPMC3063152 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Nature methods 20101031 12
The understanding of integral membrane protein (IMP) structure and function is hampered by the difficulty of handling these proteins. Aqueous solubilization, necessary for many types of biophysical analysis, generally requires a detergent to shield the large lipophilic surfaces of native IMPs. Many proteins remain difficult to study owing to a lack of suitable detergents. We introduce a class of amphiphiles, each built around a central quaternary carbon atom derived from neopentyl glycol, with h ...[more]