Ontology highlight
ABSTRACT:
SUBMITTER: Kaeser PS
PROVIDER: S-EPMC3063406 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Kaeser Pascal S PS Deng Lunbin L Wang Yun Y Dulubova Irina I Liu Xinran X Rizo Josep J Südhof Thomas C TC
Cell 20110101 2
At a synapse, fast synchronous neurotransmitter release requires localization of Ca(2+) channels to presynaptic active zones. How Ca(2+) channels are recruited to active zones, however, remains unknown. Using unbiased yeast two-hybrid screens, we here identify a direct interaction of the central PDZ domain of the active-zone protein RIM with the C termini of presynaptic N- and P/Q-type Ca(2+) channels but not L-type Ca(2+) channels. To test the physiological significance of this interaction, we ...[more]