Ontology highlight
ABSTRACT:
SUBMITTER: Lopez CA
PROVIDER: S-EPMC3063748 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
López Cesar A CA de Vries Alex H AH Marrink Siewert J SJ
PLoS computational biology 20110324 3
The depletion of cholesterol from membranes, mediated by β-cyclodextrin (β-CD) is well known and documented, but the molecular details of this process are largely unknown. Using molecular dynamics simulations, we have been able to study the CD mediated extraction of cholesterol from model membranes, in particular from a pure cholesterol monolayer, at atomic resolution. Our results show that efficient cholesterol extraction depends on the structural distribution of the CDs on the surface of the m ...[more]