Ontology highlight
ABSTRACT:
SUBMITTER: Drosatos K
PROVIDER: S-EPMC3064003 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
American journal of physiology. Endocrinology and metabolism 20101207 3
Normal hearts have increased contractility in response to catecholamines. Because several lipids activate PKCs, we hypothesized that excess cellular lipids would inhibit cardiomyocyte responsiveness to adrenergic stimuli. Cardiomyocytes treated with saturated free fatty acids, ceramide, and diacylglycerol had reduced cellular cAMP response to isoproterenol. This was associated with increased PKC activation and reduction of β-adrenergic receptor (β-AR) density. Pharmacological and genetic PKC inh ...[more]