Ontology highlight
ABSTRACT:
SUBMITTER: Noe F
PROVIDER: S-EPMC3064371 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Noé Frank F Doose Sören S Daidone Isabella I Löllmann Marc M Sauer Markus M Chodera John D JD Smith Jeremy C JC
Proceedings of the National Academy of Sciences of the United States of America 20110302 12
There is a gap between kinetic experiment and simulation in their views of the dynamics of complex biomolecular systems. Whereas experiments typically reveal only a few readily discernible exponential relaxations, simulations often indicate complex multistate behavior. Here, a theoretical framework is presented that reconciles these two approaches. The central concept is "dynamical fingerprints" which contain peaks at the time scales of the dynamical processes involved with amplitudes determined ...[more]