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Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory.

ABSTRACT: Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.

SUBMITTER: Murray AJ

PROVIDER: S-EPMC3064406 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory.

Murray Andrew J AJ Sauer Jonas-Frederic JF Riedel Gernot G McClure Christina C Ansel Laura L Cheyne Lesley L Bartos Marlene M Wisden William W Wulff Peer P

Nature neuroscience 20110130 3

Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory. ...[more]

PMID: 21278730

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