A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines.
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ABSTRACT:
SUBMITTER: Qiao K
PROVIDER: S-EPMC3064727 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
A fungal nonribosomal peptide synthetase module that can synthesize thiopyrazines.
Qiao Kangjian K Zhou Hui H Xu Wei W Zhang Wenjun W Garg Neil N Tang Yi Y
Organic letters 20110308 7
A nonribosomal peptide synthetase-like enzyme (NRPS325) from Aspergillus terreus was reconstituted in vitro and was shown to synthesize thiopyrazines using an unprecedented mechanism. Substrate promiscuity of NRPS325 toward different amino acids and free thiols was explored to produce >60 different thiopyrazine compounds. ...[more]
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