The Vibrio cholerae virulence regulatory cascade controls glucose uptake through activation of TarA, a small regulatory RNA.
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ABSTRACT:
SUBMITTER: Richard AL
PROVIDER: S-EPMC3064952 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
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The Vibrio cholerae virulence regulatory cascade controls glucose uptake through activation of TarA, a small regulatory RNA.
Richard Aimee L AL Withey Jeffrey H JH Beyhan Sinem S Yildiz Fitnat F DiRita Victor J VJ
Molecular microbiology 20100930 5
Vibrio cholerae causes the severe diarrhoeal disease cholera. A cascade of regulators controls expression of virulence determinants in V. cholerae at both transcriptional and post-transcriptional levels. ToxT is the direct transcription activator of the major virulence genes in V. cholerae. Here we describe TarA, a highly conserved, small regulatory RNA, whose transcription is activated by ToxT from toxboxes present upstream of the ToxT-activated gene tcpI. TarA regulates ptsG, encoding a major ...[more]
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